Humulin N contains insulin isophane, also known as NPH insulin, which has been modified so that it can have a longer duration of action. It is classified as an intermediate-acting insulin and has a slower onset of action than Humulin R (about 90 minutes after injection) and a longer duration of effect that can last up to 24 hours. Intermediate-acting insulin is a background or basal insulin because it provides you with an entire day’s worth of blood sugar level control. Humulin-N is structurally identical to normal insulin but it has protamines, which are small proteins, mixed in to slow down its onset and expand its length of action to last the whole day.
Your dose of Humulin N will likely be specific to you and adjusted based on your specific metabolic needs, blood sugar level monitoring results and blood sugar level control goals. Dosage adjustments may be needed if there are changes in your physical activity, meal patterns (such as nutrient content or timing of meals), in kidney or liver function or if you develop a serious illness.